A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus.  Can be seen in ETOH, pyrazinamide, lead and benzene.

A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus. Can be seen in ETOH, pyrazinamide, lead and benzene.

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Sideroblastic anemia - Causes, Diagnosis, Treatment, Ongoing care and Clinical pearls

Ring Sideroblasts in Sideroblastic Anemia. BM.

Ring Sideroblasts in Sideroblastic Anemia.

Ringed sideroblast sideroblastic anemia

Ringed sideroblast sideroblastic anemia

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

Sideroblastic anemia - Wikipedia

Sideroblastic anemia - Wikipedia

Pappenheimer Bodies = iron granules (sideroblastic anemia)

Pappenheimer Bodies = iron granules (sideroblastic anemia)

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

Sideroblastic anemia with ringed sideroblasts

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy – Dr. Mohammed AlKhateeb – Dr Mohammed AlKhateeb's Medical Blog

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy – Dr. Mohammed AlKhateeb – Dr Mohammed AlKhateeb's Medical Blog

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.

Fatty Acid Oxidation Beta Oxidation in mitocondria @ ~22:14mins Acyl- vs Acetyl CoA I put this in here b/c B12 is important for production of Succinyl Co A (Sideroblastic Anemia) AND Fatty Acid break is loosely related to this by methymaonly Co A,

Fatty Acid Oxidation Beta Oxidation in mitocondria @ Acyl- vs Acetyl CoA I put this in here b/c is important for production of Succinyl Co A (Sideroblastic Anemia) AND Fatty Acid break is loosely related to this by methymaonly Co A,

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM.  All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Correlate with Pathophysiology! A 44 year old woman with worsening fatigue, tingling and numbness in bilateral lower extremities. Past Medical history of gastric bypass surgery and current use of dentures!

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